Dr. Jonathan Thon
Harvard Medical School, USA
Research: We are making functional platelets for human infusion. Platelets are essential for hemostasis, and platelet transfusionsare widely used to treat patients with inherited or acquired thrombocytopenia. Consequently, the limited availability of donor platelets owing to their 5-day shelf life, immunogenicity of platelet products, and risk of sepsis due to bacterial contamination are of serious clinical concern. New strategies for generating platelets in vitro from non-donor dependent sources are necessary to obviate these risks and meet transfusion needs. My Research Goals are to develop a bio-mimetic system to study the cell biological and molecular pathways involved in platelet production, and produce useable numbers of clinically viable human platelets for infusion.
Dr. Mariano Barbacid
El Centro Nacional de Investigaciones Oncológicas (CNIO), Spain
Research: His work led in 1982 to the isolation of the first human oncogene and the first mutation associated with the development of human cancer. These findings, also made independently by two other groups, have been seminal to establish the molecular bases of human cancer.
Prof. Ludmilla Morozova-Roche
Umeå University, Sweden
Research: Prof. Ludmilla Morozova-Roche is a Professor of Medical Biophysics at the Umeå University in Sweden. Her work focuses on the role of inflammation and amyloid formation in neurodegeneration diseases including Alzheimer’s, Parkinson’s diseases and traumatic brain injury. In particular, her research addresses early events in fibrillation process and the molecular and cellular mechanisms of amyloid toxicity.
Prof. Robert Goldman
Feinberg School of Medicine, Northwestern University Chicago, USA
Research: We study the structure, function and dynamic properties of intermediate filaments in essential mammalian cell biological phenomena. Our work focuses on the role of cytoskeletal intermediate filaments in regulating cell shape, mechanics, signal transduction, adhesion, cell motility and molecular cross talk with microtubules and microfilaments. We are also determining the roles of the nuclear lamins in regulating nuclear architecture and chromatin organization.
Prof. Anna Smed Sörensen
Karolinska Institute Solna, Sweden
Research: With every breath we expose our lungs to foreign material that our immune system needs to tolerize or fight. Therefore it may not be surprising that acute respiratory infections caused by inhaled viruses such as Influenza or Hanta viruses are the most frequent reason for medical consultations in the world. Infection or inflammation is often restricted to a particular site in the body and Dendritic Cells are different depending on their anatomical distribution. Therefore, an important originality of our work is that we study immune cells of the respiratory system, the site of infection and inflammation. We work in close collaboration with physicians to collect endobronchial biopsies and bronchoalveolar lavage fluid and cells following bronchoscopy, as well as blood, and apply a range of sophisticated immunological and cell biological methods to understand the detailed function of DCs. If we can correlate the phenotype and function of DCs, the immune cells that present antigen to T cells, to clinical parameters, this project could aid in the identification of novel biomarkers, as well as prepare ground for new treatments for pulmonary conditions.
Dr. Andreas Diepold
Max Planck Institute for Terrestrial Microbiology Marburg, Germany
Research: Bacteria that live in contact to eukaryotic cells greatly benefit from being able to manipulate host cell behaviour. One of the most direct and elegant ways to reach this aim is the type III secretion system (T3SS), a molecular syringe also known as “injectisome”, used by gram-negative bacteria to inject effector proteins into host cells. The T3SS is essential for virulence in many important human pathogens, including Salmonella, Shigella, and pathogenic Escherichia coli, that cause several millions of deaths per year. My group wants to understand how the T3SS works on the molecular level, how it is activated and regulated during the infection process, and how we can control or inhibit its function. To this aim, we analyze the T3SS in live bacteria. We recently found that the T3SS is a dynamic molecular machine, which can quickly adapt its assembly and function to external cues. We now aim to find out how bacteria use protein dynamics for secretion, and how this increases their chance of survival during infection.